NatureNature Reviews Nephrology - AOP - nature.com science feeds

1. Hypertension: AT1 receptors might protect the kidney during hypertension
2. Diabetes: Treatments for type 2 diabetes do not affect renal function
3. Transplantation: Renal retransplanation resolves recurrent primary FSGS
4. Role of dietary therapies in the prevention and treatment of hypertension
   Hypertension is a global health challenge that is associated with increased morbidity and mortality. Modification of dietary factors such as sodium, potassium and protein has potential to reduce blood pressure, attenuate the rise in blood pressure with age, and improve the efficacy of antihypertensive therapy. The authors of this Review discuss various dietary approaches that have been shown to modify blood pressure and improve outcomes.
5. Pre-eclampsia: New method to detect podocyturia in pre-eclampsia
6. Assessment of kidney function: UACR—two risk markers or a 24 h collection in a minute?
   Increased urinary excretion of albumin and creatinine is associated with renal and cardiovascular events. Should the urinary albumin-to-creatinine ratio be considered a combination of two independent risk markers, or is it simply an easy way to obtain the same prognostic information as from a 24 h urine collection?
7. Therapy: Caution necessary when prescribing fibrates in the elderly
8. Acute kidney injury: New approach to measure RBF
9. Basic research: Inhibitor of FLC–THP binding prevents AKI in myeloma kidney
10. Therapy: Azithromycin and decolonization after HUS
    An observational study associates azithromycin use with accelerated stool decolonization in patients infected with Shiga toxin-producing Escherichia coli O104:H4. Even if this association is causal, however, the value of late-in-illness treatment is not established and the results provide no support for early-in-illness treatment of Shiga toxin-producing E. coli infections.
11. Hemodialysis: Influenza vaccine in dialysis patients—time for a reappraisal
12. Cardiovascular disease: Modifiable risk factors for sudden death in dialysis patients
    Sudden death is very common in patients on dialysis, and identifying factors that may lower the risk of sudden death could improve survival of these patients. A recent international comparison of sudden death rates by Jadoul and colleagues gives us insight into how our clinical practice might affect rates of sudden death in dialysis patients.
13. Transplantation: The DCD-N score could identify potential DCD donors
14. Innovative strategies in living donor kidney transplantation
    Live donor kidney transplantation has decreased over the past few years and innovative strategies are needed to increase the donor pool. In this Review, Dorry Segev discusses recent clinical innovations that minimize the barrier to donation, including changes in surgical technique, kidney paired donation, incompatible transplantation as well as educational and outreach programs.
15. New strategies to optimize kidney recovery and preservation in transplantation
    Optimizing kidney preservation is a primary concern in transplantation, particularly in relation to new donor sources, such as expanded criteria donors and donation after cardiac death. Here, the authors describe emerging strategies to prevent ischemia–reperfusion injuries in donor kidneys and describe innovative interventions at the donor, graft preservation or recipient levels to improve recovery, evaluation and outcome of kidney grafts.
16. Vasculitis: Will LAMP enlighten us about ANCA-associated vasculitis?
    Two recent studies have investigated the prevalence of anti-hLAMP-2 antibodies in patients with antineutrophil cytoplasmic antibody-associated vasculitides. Results from these studies suggest that more work is needed to standardize the assays used to detect anti-hLAMP-2 antibodies in patient sera before we can estimate their true prevalence in different patient populations and assess their potential clinical utility.
17. Transplantation: Arteriolar lesions are not specific for CNI toxicity
18. Chronic kidney disease: Partial nephrectomy is associated with favorable renal outcomes in patients with small renal masses
19. Risk factors: Association between high pulse pressure and proteinuria in Japanese individuals with diabetes
20. Basic research: Pathogenic role for transglutaminase in IgAN
21. Management of polyomavirus-associated nephropathy in renal transplant recipients
    Polyomavirus-associated nephropathy (PVAN) is an important infectious complication after renal transplantation, affecting 1–10% of recipients and causing graft loss in approximately 50% of cases. This Review discusses new insights into BK virus biology and PVAN development, and describes diagnostic approaches for the detection, surveillance and therapeutic monitoring of BK virus. In addition, the author reviews strategies for reducing immunosuppression and discusses current and future prospects for specific antiviral drug development.
22. The impact of donor-specific anti-HLA antibodies on late kidney allograft failure
    Although outcomes of renal transplantation have improved in recent times, kidney allograft loss remains substantial. A major advance of the past decade has been the demonstration of the destructive power of anti-HLA alloantibodies and their association with antibody-mediated rejection (ABMR). The authors of this Review present the new entities and concepts that have emerged to expand our knowledge of the spectrum of ABMR and some aspects of the natural history of antibody-mediated kidney allograft deterioration.
23. Glomerular disease: Eculizumab for the treatment of MPGN
24. Acute kidney injury: AKI in acute myocardial infarction—are we making progress?
    A recent report suggests that the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction declined between 2000 and 2008 and was associated with decreased mortality despite concurrent increases in comorbidities. Although encouraging, changing patterns of care and an understanding of factors contributing to AKI in this setting must be considered.
25. Considerations in the optimal preparation of patients for dialysis
    Concern exists that a sizeable proportion of patients with chronic kidney disease are not adequately prepared for initiating dialysis therapy. In this Review, members of the Dialysis Advisory Group of the American Society of Nephrology discuss the challenges in preparing patients for dialysis therapy and present a practical step-by-step approach to help transition patients to renal replacement therapy.
26. Increasing the pool of deceased donor organs for kidney transplantation
    The number of candidates awaiting kidney transplantation has grown substantially over the past few decades, but the number of available organs has increased only modestly. Barring any notable progress in technology, improving the fate of transplant candidates will rely heavily on increasing the pool of available donor organs. This Review outlines prominent proposed interventions that may increase the deceased kidney donor pool and discusses issues concerning their implementation and effectiveness.
27. The Declaration of Istanbul—early impact and future potential
    The Declaration of Istanbul on Organ Trafficking and Transplant Tourism was formulated at an international meeting held in 2008 with the aim of promoting the welfare of living organ donors in the context of improved global organ transplantation practice. In this Perspectives article, Danovitch and Al-Mousawi provide an update on this endeavor, specifically discussing promulgation of the Declaration, how it has been put into action and legislative changes that have since come into effect.
28. Monocyte subpopulations and cardiovascular risk in chronic kidney disease
    A growing body of evidence indicates that monocytes, specifically intermediate (CD14++CD16+) monocytes, contribute to the development of atherogenesis and increase in number with worsening renal function. In this Review, Heine and colleagues on behalf of the EURECA-m working group of the ERA–EDTA, describe the developmental and functional characterization of monocyte subsets, with particular focus on prominent subsets in atherosclerosis and chronic kidney disease.