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  • Hi Venkat,

    I am not familiar with this drug and to my knowledge is not available in Canada (where I practice).

    However, dihydropyridine calcium channel antagonists do not have a good track record from the point of view of proteinuria,, though are excellent blood pressure drugs. In fact the most striking finding to me of the ACCOMPLISH study (linked below) was that patients on HCTZ had much lower proteinuria levels on treatment compared to those receiving amlodipine. What's even more interesting is that patients on amlodipine did better from the point of view of cardiovascular outcomes despite worsening proteinuria.

    But I will review the data you suggested above.

    Dr. Jordan Weinstein