Hello,

Using a protein to creatinine ratio would be the most inclusive, and include proteins in addition to albumin (e.g. immunoglobulins). In some examples of glomerulonephritis, albumin is the exclusive protein seen whereas in others it is only a fraction (as low as 50%).Therefore in order to be most inclusive, you cold use protein rather than albumin to creatinine ratios.

However, if using proteinuria when looking for markers of cardiovascular risk, the data are strongest for albumin to creatinine ratio elevation, not total protein to creatinine ratios.

Dr. Jordan Weinstein