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Modulating MAGnesIum and K (potassium) in dialysate: a pragmatic cluster randomised controlled trial

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Current total funding for this study: $1,169,991

Author:

Swapnil Hiremath
Nephrologist

Study Acronym:

MAGIK trial

To try to prevent sudden cardiac death we will randomize dialysis centers to either usual care or individually adjusted potassium and/or magnesium.

This is a 2x2 factorial design with centers randomized to:

  1. Usual care
  2. Usual potassium and algorithm driven magnesium
  3. Usual magnesium and algorithm driven potassium
  4. Algorithm driven potassium and magnesium

The primary outcome will be all-cause mortality.

Secondary outcomes will include: - difference in cardiovascular mortality - difference in sudden death (within cardiovascular mortality) - hospitalization for any reason

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