Modulating MAGnesIum and K (potassium) in dialysate: a pragmatic cluster randomised controlled trial
Study Acronym:MAGIK trial
To try to prevent sudden cardiac death we will randomize dialysis centers to either usual care or individually adjusted potassium and/or magnesium.
This is a 2x2 factorial design with centers randomized to:
- Usual care
- Usual potassium and algorithm driven magnesium
- Usual magnesium and algorithm driven potassium
- Algorithm driven potassium and magnesium
The primary outcome will be all-cause mortality.
Secondary outcomes will include: - difference in cardiovascular mortality - difference in sudden death (within cardiovascular mortality) - hospitalization for any reason