The aim of this proposal is to conduct a prospective, randomized trial to assess the effect of weight loss on kidney transplant outcomes. We will test whether weight loss with a fitness program plus diet or bariatric surgery is superior to usual treatment.
Inclusion Criteria • >Age 18 • Pre-emptive kidney transplant candidates, living related and deceased donors. • Patients that have been on hemodialysis or peritoneal dialysis for more than 6 months. •
Patients with BMI >40 Intervention Patients will be randomized into one of three arms:
Primary end points • Delayed wound healing. • Delayed graft function • 1 year graft survival
Secondary end points • Perioperative complications • Allograft rejection (cellular or antibody-mediated) • Hospital length of stay