1Radiology Department, Dallas VA Medical Center, Dallas, TX, USA, 2Nephrology Section, W. G. (Bill) Hefner VA Medical Center, Salisbury, NC, USA
- Image A
- Image B
Staghorn calculi can damage the kidney and/or lead to life threatening urosepsis. On plain radiograph, vast majority of staghorn calculi are radio-opaque. Associated caliceal dilatation with staghorn calculi is identified on computed tomogram (CT) scan as shown in Image A. A CT scan of a complete staghorn calculus with 3D volume rendered image iis shown in Image B.
The term “partial” or “complete” staghorn calculus designates a branched stone that occupies part or the entire pelvicaliceal system. Approximately 70% of staghorn calculi are composed of mixtures of magnesium ammonium phosphate (struvite) and/or calcium carbonate apatite. Cystine, uric acid and calcium oxalate/phosphate components rarely form staghorn calculi. The clinical characteristics that are commonly associated with staghorn configuration include: women, neurogenic bladder, ureteral diversion to ileum and recurrent urinary tract infection with urease producing bacteria (such as Proteus, Klebsiella, Pseudomonas and Enterobacter). The generation of ammonia and hydroxide from urea by these bacteria creates an alkaline environment that promotes crystallization of struvite in the urine . Treatment involves complete removal of the stone, as small residual fragments can act as a nidus for infection and recurrent stone formation. The American Urological Association (AUA) has proposed four modalities as potential therapeutic alternatives for staghorn calculi:
- Percutaneous nephrolithotomy (PNL) monotherapy
- Combination of PNL and shock-wave lithotripsy (SWL)
- SWL monotherapy; and 4. Open surgery. AUA recommends nephrectomy for non-functioning kidney with staghorn calculi and avoid SWL for staghorn formed predominantly with cystine .
Conflict of Interest
The author confirms that this article content has no conflict of interest.
 Dyer RB, Chen MY, Zagoria RJ. Classic signs in uroradiology. Radiographics 2004; 24: S247-S280.
 AUA Guideline on the Management of Staghorn Calculi: Diagnosis and Treatment Recommendations. Available at http://www.auanet.org/content/clinical-practice-guidelines/clinicalguidelines/main-reports/staghorncalculi/chapter1.pdf
*Address correspondence to this author at the Radiology Department, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA; Tel: 214-857-0185; Fax: 214-857-0173; E-mail: Pramod.Gupta@va.gov
This material is adapated with permission from The Open Urology & Nephrology Journal