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Q1. With CKD patients who had a first hyperkalemia (HK) episode, what is the approximate likelihood of a second HK event occurring?

Patients with CKD and HF tend to have recurrent hyperkalemia episodes with successively shorter time between each subsequent episode. In a large population cohort study (n = 157,766) conducted in Denmark between 2000 and 2012, it was shown that among people with CKD that had a first HK event, 42.96% had a second event, with a median time between events of 7.7 months. Patient proportions who experienced a third (57.07%) or fourth (60.10%) hyperkalemia event after previous events were even greater. Similar observations were made among HF patients1[Thomsen 2018, p. 1614/fig.2].

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Reference:

  1. Thomsen RW, Nicolaisen SK, Hasvold P, et al. Elevated potassium levels in patients with chronic kidney disease: occurrence, risk factors and clinical outcomes-a Danish population-based cohort study. Nephrol Dial Transplant. 2018 Sep 1;33(9):1610-1620. doi: 10.1093/ndt/gfx312.
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