General Recommendation
ECTR is suggested in severe APAP poisoning (2D)
Indications
Indications
ECTR is recommended
ECTR is not recommended
ECTR is not suggested
Cessation of ECTR
Choice of ECTR
The following are acceptable alternatives if HD is not available:
Miscellaneous
General Recommendation
Indications
ECTR is recommended
ECTR is suggested
Choice of ECTR
Cessation of ECTR
General Recommendation
Indications
ECTR is recommended if ANY of the following conditions are present:
ECTR is suggested if ANY of the following conditions are present:
Cessation of ECTR
Choice of ECTR
The following are alternatives if hemodialysis is not available:
Miscellaneous
General Recommendation
Indications
ECTR is recommended if ANY of the following conditions are present:
Cessation of ECTR
Choice of ECTR
Miscellaneous
General Recommendation
Indications
ECTR is recommended:
Cessation of ECTR
Choice of ECTR
General Recommendation
Indications
ECTR is indicated if ANY of the following conditions are present:
Cessation of ECTR
Choice of ECTR
General Recommendation
Indications
ECTR is recommended if ANY of the following are met:
If standard therapy (supportive measures, bicarbonate, etc.) fails (1D), ECTR is suggested if any of the following are met:
Cessation of ECTR
Is indicated if:
Choice of ECTR
The following are acceptable alternative if HD is not available:
Miscellaneous
General Recommendation
Indications
ECTR is indicated if ANY of the following conditions are present:
Cessation of ECTR
Choice of ECTR
General Recommendation
General Recommendation
Indications
ECTR is recommended if any of the following is present:
If any of the following is present:
Cessation of ECTR
Is indicated if any of the following is present:
Choice of ECTR
NB: ECTR = extracorporeal treatment
Click here for levels of evidence
Level | Therapy / Prevention, Aetiology / Harm | Prognosis | Diagnosis | Differential diagnosis / symptom prevalence study | Economic and decision analyses |
---|---|---|---|---|---|
1a | SR (with homogeneity*) of RCTs | SR (with homogeneity*) of inception cohort studies; CDR” validated in different populations | SR (with homogeneity*) of Level 1 diagnostic studies; CDR” with 1b studies from different clinical centres | SR (with homogeneity*) of prospective cohort studies | SR (with homogeneity*) of Level 1 economic studies |
1b | Individual RCT (with narrow Confidence Interval”¡) | Individual inception cohort study with > 80% follow-up; CDR” validated in a single population | Validating** cohort study with good” ” ” reference standards; or CDR” tested within one clinical centre | Prospective cohort study with good follow-up**** | Analysis based on clinically sensible costs or alternatives; systematic review(s) of the evidence; and including multi-way sensitivity analyses |
1c | All or none§ | All or none case-series | Absolute SpPins and SnNouts” “ | All or none case-series | Absolute better-value or worse-value analyses ” ” ” “ |
2a | SR (with homogeneity*) of cohort studies | SR (with homogeneity*) of either retrospective cohort studies or untreated control groups in RCTs | SR (with homogeneity*) of Level >2 diagnostic studies | SR (with homogeneity*) of 2b and better studies | SR (with homogeneity*) of Level >2 economic studies |
2b | Individual cohort study (including low quality RCT; e.g., <80% follow-up) | Retrospective cohort study or follow-up of untreated control patients in an RCT; Derivation of CDR” or validated on split-sample§§§ only | Exploratory** cohort study with good” ” ” reference standards; CDR” after derivation, or validated only on split-sample§§§ or databases | Retrospective cohort study, or poor follow-up | Analysis based on clinically sensible costs or alternatives; limited review(s) of the evidence, or single studies; and including multi-way sensitivity analyses |
2c | “Outcomes” Research; Ecological studies | “Outcomes” Research | Ecological studies | Audit or outcomes research | |
3a | SR (with homogeneity*) of case-control studies | SR (with homogeneity*) of 3b and better studies | SR (with homogeneity*) of 3b and better studies | SR (with homogeneity*) of 3b and better studies | |
3b | Individual Case-Control Study | Non-consecutive study; or without consistently applied reference standards | Non-consecutive cohort study, or very limited population | Analysis based on limited alternatives or costs, poor quality estimates of data, but including sensitivity analyses incorporating clinically sensible variations. | |
4 | Case-series (and poor quality cohort and case-control studies§§) | Case-series (and poor quality prognostic cohort studies***) | Case-control study, poor or non-independent reference standard | Case-series or superseded reference standards | Analysis with no sensitivity analysis |
5 | Expert opinion without explicit critical appraisal, or based on physiology, bench research or “first principles” | Expert opinion without explicit critical appraisal, or based on physiology, bench research or “first principles” | Expert opinion without explicit critical appraisal, or based on physiology, bench research or “first principles” | Expert opinion without explicit critical appraisal, or based on physiology, bench research or “first principles” | Expert opinion without explicit critical appraisal, or based on economic theory or “first principles” |