| Iron salt | Dose (mg) | Elemental Iron (mg) | Cost* |
| Ferrous gluconate | 300 | 35 | $0.10 |
| Ferrous sulfate | 300 | 60 | $0.04 |
| Ferrous fumarate | 300 | 100 | $0.10-0.35 |
Other oral formulations may be used if the patient is intolerant or experiences gastro-intestinal side effects.
| Oral iron | Dose (mg) | Elemental Iron (mg) | Cost* |
| Polysaccharide | 150 | 150 | $0.56-0.70 |
| Heme iron | 398 | 11 | $0.77 |
*Estimates: Costs may differ across Canada Here are the different IV iron formulations available in Canada.
| iron sucrose | sodium ferric gluconate complex in sucrose | iron isomaltoside | |||
| Indication | IDA in CKD (NDD, HDD, PDD) | IDA in HDD + ESA | IDA | ||
| Carbohydrate | Sucrose (disaccharide) | Gluconate (monosaccharide) | Isomaltoside (linear oligosaccharide) | ||
| Strength (mg/mL) | 20 | 12.5 | 100 | ||
| Max. single dose | 300 mg | 125 mg | 20 mg/kg (doses >1500 mg not recommended) | ||
| Administration and time | IV bolus: 2–5 min. IV infusion: 1.5–4 hours | IV infusion: 1 h | IV bolus: 500 mg/2 min. IV infusion: ≤1000 mg/ ≥20 min. >1000 mg/ ≥30 min. | ||
CKD=Chronic kidney disease, NDD=Non-dialysis dependent, HDD=hemodialysis-dependent, PDD=Peritoneal-dialysis-dependent, ESA= Erythropoiesis-stimulating agents
References
- American regent, Inc. Pr Venofer® Product Monograph. Date of Preparation: January 23, 2019
- Pfizer Canada Inc Pr MonoferricTM Product Monograph. Date of Preparation: June 22, 2018
- Sanofi-aventis Canada Inc. Ferrlecit® Product Monograph. Date of Preparation: December 13, 2019
- Muñoz M, et al. Exp Opin Drug Saf. 2018;17(2):149-59
- Auerbach M, et al. Hematology Am Soc Hematol Educ Program. 2016;2016(1):57-66
- Zeller MP, et al. CMAJ. 2017; 189(10):E409; Tolkien Z, et al. PLoS One. 2015; 10(2): e0117383
- DeLoughery TG. Acta Haematol. 2019; 142(1):8-12
- Auerbach M, et al. UpToDate. Last Updated July 2020
- Muñoz M, et al. Anaesthesia. 2017;72(2):233-47
