Dialysis Prescription
If technically simple, consider increasing dialysate calcium by 0.25 – 0.50 mmol/L (0.50-1.00 mEq/L).
Phosphate and Calcium Management
Counseling about phosphate in the diet and the timing of binders with respect to meals is required
Phosphate Binders
Therapeutic avenues;
PTH Management
Vitamin D Sterols
This constellation of parameters strongly suggests active vitamin D deficiency; measure serum 25 OH D. Therapeutic avenues;
Calcimimetics
An expensive alternative, if the only reason for starting cinecalcet is the high serum PTH (see above). If already on cinecalcet, increase the dose, or add treatment with a vitamin D analogue to achieve normal serum calcium levels.
Suggested Guidelines include;
CSN
7. Vitamin D sterols can be used in the treatment of secondary hyperparathyroidism, but should be discontinued when PTH levels decrease below target levels, or if calcium or phosphate levels increase above target levels.(Grade C)
KDIGO
4.2.1 In patients with CKD stages 3–5 not on dialysis, the optimal PTH level is not known. However, we suggest that patients with levels of intact PTH (iPTH) above the upper normal limit of the assay are first evaluated for hyperphosphatemia, hypocalcemia, and vitamin D deficiency (2C). It is reasonable to correct these abnormalities with any or all of the following: reducing dietary phosphate intake and administering phosphate binders, calcium supplements, and/or native vitamin D (not graded).
4.2.3 In patients with CKD stage 5D, we suggest maintaining iPTH levels in the range of approximately two to nine times the upper normal limit for the assay (2C). We suggest that marked changes in PTH levels in either direction within this range prompt an initiation or change in therapy to avoid progression to levels outside of this range (2C).
4.2.4 In patients with CKD stage 5D and elevated or rising PTH, we suggest calcitriol, or vitamin D analogs, or calcimimetics, or a combination of calcimimetics and calcitriol or vitamin D analogs be used to lower PTH (2B).
a) It is reasonable that the initial drug selection for the treatment of elevated PTH be based on serum calcium and phosphorus levels and other aspects of CKD–MBD (not graded).
b) It is reasonable that calcium or non-calcium-based phosphate binder dosage be adjusted so that treatments to control PTH do not compromise levels of phosphorus and calcium (not graded).
e) We suggest that, in patients with hypocalcemia, calcimimetics be reduced or stopped depending on severity, concomitant medications, and clinical signs and symptoms (2D).
f) We suggest that, if the intact PTH levels fall below two times the upper limit of normal for the assay, calcitriol, vitamin D analogs, and/or calcimimetics be reduced or stopped (2C).
Other Options or Controversies in Management
Parathyroidectomy
There is no indication for parathyroidectomy. The high serum PTH is more likely to be secondary to nutritional issues (see above), rather than autonomous hyperparathyroidism
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