Hello,
I would not be concerned about impending kidney failure - not at all.
The fact that your urinary protein is zero and that your creatinine is not progressively rising, I would not rate your risk of kidney failure as significant whatsoever. Creatinine fluctuation can indeed happen, especially when taking losartan. In fact, if you plot your tests in the KFRE equation (
https://ukidney.com/nephrology-resources/kidney-failure-risk-calculator), your risk of kidney failure in the next 2 and 5 years is essentially 0%. And assuming your results remain in their current ranges (as they have for last 14 years), there is no reason to be believe this will change over time. When performing blood tests, ensure that you are well-hydrated as this one fact can influence your creatinine level, especially when taking losartan. Also, ensure that you refrain from smoking, have good cholesterol control and ideally avoid NSAIDs.
I can only base my opinion on the information provided and your health-care provider might arrive at different conclusions once you have provided an entire history and had a physical examination performed. As always, this forum provides general medical information only and is limited to educational use only. Please discuss the above remarks with your health-care provider.
Dr. Jordan Weinstein