Hello again,
From your family history, it would appear that you have the PKD2 variant. This form of the disease is generally more indolent and many patients never go on to develop end-stage kidney disease. While your father was not old enough to view the natural history of his illness to prove this fact, his parents did not sound like they had significant disease, and given the fact that the diseases autosomal dominant, one of them very likely had it.
Therefore, all of my advice remains the same from the original post. You will have to have your cyst growth and kidney function monitored. Only time will tell whether you are likely to progress although my instincts tell me you're not likely to do so. As well, there is a new medication available for patients with PKD called tolvaptan (
see blog post), which in initial studies has been shown to delay the progression of PKD. It is still early in the lifecycle of this drug and we are learning how to prescribe it and to whom, but it is very promising indeed. I am glad that you are going to discuss this with your family doctor, but in addition you should also be followed by a nephrologist, ideally one with an interest in polycystic kidney disease.
Dr. Jordan Weinstein