Diabetic Kidney Disease

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy (RENAAL)

N Engl J Med. 2001 Sep 20;345(12):861-9

Randomized Trial SHSC Visual Abstract

Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study Group

Maschio G, Alberti D, Janin G, Locatelli F, Mann JF, Motolese M, Ponticelli C, Ritz E, Zucchelli P

N Engl J Med. 1996 Apr 11;334(15):939-45

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris, M.D., Rajiv Agarwal, M.D., Stefan D. Anker, M.D., Ph.D., Bertram Pitt, M.D., Luis M. Ruilope, M.D., Peter Rossing, M.D., Peter Kolkhof, Ph.D., Christina Nowack, M.D., Patrick Schloemer, Ph.D., Amer Joseph, M.B., B.S., and Gerasimos Filip

Dapagliflozin in Patients with Chronic Kidney Disease

Hiddo J.L. Heerspink, Ph.D., Bergur V. Stefánsson, M.D., Ricardo Correa-Rotter, M.D., Glenn M. Chertow, M.D., Tom Greene, Ph.D., Fan-Fan Hou, M.D., Johannes F.E. Mann, M.D., John J.V. McMurray, M.D., Magnus Lindberg, M.Sc., Peter Rossing, M.D., C. David S

2020 Oct 8;383(15):1436-1446

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

EMPEROR-Reduced Trial Investigators

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

Vlado Perkovic, M.B., B.S., Ph.D., Meg J. Jardine, M.B., B.S., Ph.D., Bruce Neal, M.B., Ch.B., Ph.D., Severine Bompoint, B.Sc., Hiddo J.L. Heerspink, Pharm.D., Ph.D., David M. Charytan, M.D., Robert Edwards, M.P.H., Rajiv Agarwal, M.D., George Bakris, M.D

Meta-analysis

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Stephen D. Wiviott, M.D., Itamar Raz, M.D., Marc P. Bonaca, M.D., M.P.H., Ofri Mosenzon, M.D., Eri T. Kato, M.D., M.P.H., Ph.D., Avivit Cahn, M.D., Michael G. Silverman, M.D., M.P.H., Thomas A. Zelniker, M.D., Julia F. Kuder, M.A., Sabina A. Murphy, M.P.H

SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

CREDENCE Trial Investigators

Meta-analysis

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M, Matthews DR; CANVAS Program Collaborative Group

N Engl J Med. 2017 Jun 12. doi: 10.1056/NEJMoa1611925

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

Wanner C, Inzucchi SE, Lachin JM, Fitchett D, von Eynatten M, Mattheus M, Johansen OE, Woerle HJ, Broedl UC, Zinman B; EMPA-REG OUTCOME Investigators

N Engl J Med. 2016 Jul 28;375(4):323-34. doi: 10.1056/NEJMoa1515920

Visual Abstract

Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications

Hiddo J.L. Heerspink, Bruce A. Perkins, David H. Fitchett, Mansoor Husain, David Z. I. Cherney

Circulation. 2016 Sep 6;134(10):752-72

Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy

Linda F. Fried, M.D., M.P.H., Nicholas Emanuele, M.D., Jane H. Zhang, Ph.D., Mary Brophy, M.D., Todd A. Conner, Pharm.D., William Duckworth, M.D., David J. Leehey, M.D., Peter A. McCullough, M.D., M.P.H., Theresa O'Connor, Ph.D., Paul M. Palevsky, M.D., R

N Engl J Med 2013; 369:1892-1903November 14, 2013

Diabetic Kidney Disease Hypertension

Effects of intensive blood-pressure control in type 2 diabetes mellitus

ACCORD Study Group, Cushman WC, Evans GW, Byington RP, Goff DC Jr, Grimm RH Jr, Cutler JA, Simons-Morton DG, Basile JN, Corson MA, Probstfield JL, Katz L, Peterson KA, Friedewald WT, Buse JB, Bigger JT, Gerstein HC, Ismail-Beigi F

N Engl J Med. 2010 Apr 29;362(17):1575-85

Modern-Day Clinical Course of Type 1 Diabetes Mellitus After 30 Years’ Duration

Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ

Arch Intern Med. 2009 Jul 27;169(14):1307-16