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Autosomal Dominant Polycystic Kidney Disease (ADPKD) Wall of Experts

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Natural History

How does the genetic profile of ADPKD impact the disease course?

Dr. York Pei

How does the genetic profile of ADPKD impact the disease course?

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What is the typical pattern of cyst development and progression in ADPKD?

Dr. Phil McFarlane

What is the typical pattern of cyst development and progression in ADPKD?

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What are the risk factors for ADPKD disease progression?

Dr. Neera Dahl

What are the risk factors for ADPKD disease progression?

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What is the relationship between growth in kidney volume and kidney function in ADPKD?

Dr. Phil McFarlane

What is the relationship between growth in kidney volume and kidney function in ADPKD?

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Should we be screening for intracranial aneurysms in ADPKD patients?

Dr. Navdeep Tangri

Should we be screening for intracranial aneurysms in ADPKD patients?

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Diagnosis

How do you diagnose ADPKD and what is the role of genetic testing?

Dr. Ahsan Alam

How do you diagnose ADPKD and what is the role of genetic testing?

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What is the role of TKV in practice?

Dr. Neera Dahl

What is the role of TKV in practice?

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How should we assess total kidney volume?

Dr. Neera Dahl

How should we assess total kidney volume?

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Treatment

What is the evidence supporting the use of water therapy for ADPKD?

Dr. York Pei

What is the evidence supporting the use of water therapy for ADPKD?

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What is the presumed mechanism of action of tolvaptan in ADPKD?

Dr. Phil McFarlane

What is the presumed mechanism of action of tolvaptan in ADPKD?

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What role can modulation of the RAAS and blood pressure play in the treatment of ADPKD?

Dr. Ahsan Alam

What role can modulation of the RAAS and blood pressure play in the treatment of ADPKD?

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What are the data supporting use of Tolvaptan for ADPKD?

Dr. Neera Dahl

What are the data supporting use of Tolvaptan for ADPKD?

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What is the status of the evidence for the use of mTOR inhibitors for ADPKD?

Dr. Paul Tam

What is the status of the evidence for the use of mTOR inhibitors for ADPKD?

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How is tolvaptan dosed and titrated?

Dr. Philip McFarlane

How is tolvaptan dosed and titrated?

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What potential drug interactions should we be aware of with tolvaptan?

Dr. Paul Tam

What potential drug interactions should we be aware of with tolvaptan?

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What is the tolvaptan Hepatic Safety and Monitoring Programme (HSMP)?

Dr. Navdeep Tangri

What is the tolvaptan Hepatic Safety and Monitoring Programme (HSMP)?

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What is the liver toxicity profile of tolvaptan in ADPKD?

Dr. York Pei

What is the liver toxicity profile of tolvaptan in ADPKD?

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What is the presumed mechanism of action of tolvaptan and what is the evidence of efficacy?

Dr. Navdeep Tangri

What is the presumed mechanism of action of tolvaptan and what is the evidence of efficacy?

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What happens if you stop tolvaptan therapy?

Dr. Neera Dahl

What happens if you stop tolvaptan therapy?

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Accredited Program

This activity is an accredited simulation activity (Section 3) as defined by the Maintenance of Certification program of the Royal College of Physicians and Surgeons of Canada and approved by the Canadian Society of Nephrology at the end of June and expires June 2016


This program was supported with financial assistance from Otsuka Canada. All content was independently produced by the experts herein without any direction from Otsuka Canada.

{SCOpenGraph description=ADPKD Wall of Experts At the end of the program, participants will be able to: Review the genetics of Autosomal Dominant Polycystic Kidney Disease (ADPKD) Discuss the clinical heterogeneity of disease progression in ADPKD Examine the role of genetics and total kidney volume (TKV) as major clinical prognostic measures} {SCOpenGraph title=Autosomal Dominant Polycystic Kidney Disease (ADPKD) Wall of Experts}

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